Mechanism of Action:
The cell wall of gram-negative bacteria is thin (a few nanometers thick). This can be easily penetrated by the nanoparticles.
- Disruption of the cell wall and cytoplasmic membrane.
- The cytoplasm leaks out, and the cell structure disintegrates.
- Inhibition of DNA replication and disruption of signal transduction.
- The disintegration of the entire cell membrane by ROS and lipid peroxidation.
- Death of the cell
Reference:
Mikhailova EO. Silver Nanoparticles: Mechanism of Action and Probable Bio-Application. J Funct Biomater. 2020 Nov 26;11(4):84. doi: 10.3390/jfb11040084. PMID: 33255874; PMCID: PMC7711612.
Anjum, S., Jacob, G. & Gupta, B. Investigation of the herbal synthesis of silver nanoparticles using Cinnamon zeylanicum extract. emergent mater. 2, 113–122 (2019). https://doi.org/10.1007/s42247-019-00023-x
