Silver nano-particles antimicrobial action mechanism against gram-negative Escherichia coli bacteria

Mechanism of Action:

The cell wall of gram-negative bacteria is thin (a few nanometers thick). This can be easily penetrated by the nanoparticles.

1. Disruption of the cell wall and cytoplasmic membrane.
2. The cytoplasm leaks out, and the cell structure disintegrates.
3. Inhibition of DNA replication and disruption of signal transduction.
4. The disintegration of the entire cell membrane by ROS and lipid peroxidation.
5. Death of the cell

Reference:

Mikhailova EO. Silver Nanoparticles: Mechanism of Action and Probable Bio-Application. J Funct Biomater. 2020 Nov 26;11(4):84. doi: 10.3390/jfb11040084. PMID: 33255874; PMCID: PMC7711612.

Anjum, S., Jacob, G. & Gupta, B. Investigation of the herbal synthesis of silver nanoparticles using Cinnamon zeylanicum extract. emergent mater. 2, 113–122 (2019). https://doi.org/10.1007/s42247-019-00023-x